NORIP is a Nordic project with the goal to recommend Nordic serum/plasma reference intervals for 25 of the most common quantities used in clinical chemistry. |
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| Basic concept | |
Participating laboratories receive five reference
materials on dry ice of which one (CAL), will function as a calibrator for the
reference values. The participating
laboratories will collect blood samples from at least 25 reference individuals evenly
distributed on age and gender. In addition to the material needed for local measurement,
seven replicates each of 1 mL of serum, two of plasma and one of buffycoat from EDTA-blood
are to be collected, frozen at -80°C and sent to a central bio-bank. The default
concept is to freeze serum samples until measurement, but laboratories are invited also to
measure on fresh plasma and serum if possible. Each reference
individual answer a questionnaire with personal information relevant for evaluation of
reference intervals. Samples and
reference materials are measured in one series and results reported together with
information on reference individuals and analytical methods. Reference
intervals are computed centrally. After project is
finished, the bio- and data bank will be administered by Nordic Society of Clinical
Chemistry (NFKK). |
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| Results | |
| 102 laboratories, 21 from Denmark, 26 from Finland, 1 from Iceland, 30 from Norway and 24 from Sweden have collected samples from 3035 individuals resulting in 124 744 reference values, 42 964 on plasma and 81 757 on serum. Other preliminary results are presented on this internet home site. | |